Peripheral neuropathy is damage to the peripheral nerves and results in a tingling, painful, or burning sensation in the extremities. It most commonly occurs in the legs. Other symptoms of peripheral neuropathy can include weakness and numbness. Poorly controlled diabetes is one of the most common causes of peripheral neuropathy, but a number of conditions can be responsible for damage to the peripheral nerves. Examples of other causes include alcoholism, kidney failure, vitamin deficiency, and shingles. Some medications, including certain cancer chemotherapy drugs, can cause peripheral neuropathy.